|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
We suggest that this CD screening protocol may be individualized according to the DQA1*05-DQB1*0201 positivity.
|
11195230 |
2000 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
We selected 38 consecutive celiac disease (CD) patients (from a group of 316 consecutive CD patients) and 91 healthy blood donors, all of whom were HLA-DQ2 (DQA1*0501/DQB1*0201) negative, and investigated the presence of the classically associated alleles HLA-DQ8 and HLA-DRB4.
|
11862400 |
2002 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We retrospectively reviewed the medical records of 127 consecutive cases of adult-onset celiac disease evaluated at a single United States center to determine the distribution of the associated human leukocyte antigen DQA1 and DQB1 alleles.
|
21292306 |
2011 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
We propose the use of the DQ-CD Typing kit that allows identification of the HLA class II alleles (DQA1*0201,*03,*05, DQB1*02,*0302, DRB1*03,*04,*07) selected to be informative in the CD risk evaluation and of a second kit, namely DQ-CD Zygosis, for DQB1*02 homozygosity determination.
|
18076355 |
2008 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We propose that, in individuals carrying the DQA1*0501 and DQB1*0201 alleles, the presence of a second copy of the DQB1*0201 allele increases susceptibility to CD.
|
8362409 |
1993 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We like to suggest that the haplotype HLA-DQA1*03-DQB1*03:03 (HLA-DQ9.3), which is common in Chinese, is a new susceptibility factor for CD in China.
|
26496305 |
2015 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
We have developed and validated CD-loop-mediated isothermal amplification (CD-LAMP), a LAMP assay, which enables rapid identification of the signature CD risk genotypes, HLA-DQ2.5, HLA-DQ8, HLA-DQ2.2, and HLA-DQA1*05.
|
29458095 |
2018 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Typing of DNA from 94 unrelated children with celiac disease (CD) with HLA-DQA1 and -DQB1 allele-specific oligonucleotide probes revealed that all but one (i.e., 98.9%) may share a particular combination of a DQA1 and a DQB1 gene.
|
2909659 |
1989 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To predict the HLA-DQA1 and -DQB1 genes, we used six previously reported HLA-tagging single nucleotide polymorphism to determine HLA genotypes in 59 Iranian patients with 'biopsy-confirmed' CD and in 151 healthy Iranian individuals.
|
24876751 |
2014 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To elucidate the HLA DRB1, DQB1 and DQA1 polymorphism in Tunisian children with typical form of coeliac disease (CD) in comparison with those from mass screening (atypical and silent CD).
|
19474744 |
2009 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Thus, the celiac disease associated DQA1 and DQB1 genes encode a functionally expressed DQ alpha/beta heterodimer.
|
1972714 |
1990 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Three non-biopsied DS patients had also most probably CD because DQA1*0501/DQB1*0201 and IgA anti-tTG (EMA) were detected.
|
16552815 |
2006 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study confirms the existing data and provides additional evidence supporting a strong genetic predisposition for CD associated with the class II alleles DQB1*02 and DQA1*05 encoding the serological specificity DQ2.
|
23041663 |
2012 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study confirms that the MHC-linked celiac disease susceptibility among Ashkenazi Jews is closely associated with the presence of the combination of alleles DQA1*0501 DQB1*0201.
|
8138422 |
1993 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
There is a tight HLA association between CD and the HLA DQ alleles DQA1*0501, DQB1*0201 (DQ2), arranged in either cis- or trans- configuration, are found in 98.9% of cases in Northern European populations and 80% in Greeks and Ashkenazi Jews resident in Israel.
|
9659975 |
1998 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
The vast majority of these T cells recognize gluten peptides when presented by HLA-DQ2 (DQA1*05/DQB1*02), a molecule which immunogenetic studies have identified as conferring susceptibility to CD.
|
11673490 |
2001 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
The role of human leukocyte antigen (HLA) DQ2 heterodimer (DQA1*0501-DQB1*0201) in presenting gluten peptides to effector T cells in celiac disease (CD) has been well documented.
|
12121676 |
2002 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The risk for celiac disease (CD) is clearly related to specific HLA DQA1 and DQB1 alleles, but HLA -typing is often considered too costly for frequent use.Here we present a method using sequence-specific primed PCR (PCR-SSP) for HLA-DR-DQ genotyping optimized for capillary electrophoresis on Applied Biosystems 3130xl Genetic Analyzer.
|
22976110 |
2013 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The results indicate that the risk of CD in children with type 1 diabetes is significantly modified both by the presence of HLA-DQB1*02-DQA1*05 and by a variant of another gene within the major histocompatibility complex, the TNF -308A.
|
16567828 |
2006 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
The primary HLA association in the majority of celiac disease patients is with DQ2 (DQA1*05/DQB1*02) and in the minority of patients with DQ8 (DQA1*0301/DQB1*0302).
|
11501889 |
2001 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The primary association of CD with the DQA1*0501 and DQB1*0201 alleles, rather than with HLA haplotypes, was confirmed in multiplex families.
|
8803535 |
1996 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The prevalence of the HLA-DQA1 and DQB1 alleles in 55 Turkish children with celiac disease and 50 control subjects was investigated by using an allele-specific DNA-based polymerase chain reaction-sequence-specific primer (PCR-SSP) method.
|
11556984 |
2001 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
The presence of the DQ2 (DQA1*0501/DQB1*02) heterodimer is strongly associated with celiac disease in the population studied by the authors.
|
14581805 |
2003 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
The heterodimer HLA-DQB1*0201/-DQA1*0501, present in 96% of our patients, is strongly associated with CD susceptibility, confirming published reports.
|
8590546 |
1995 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The guanine-to-adenine polymorphism at position -308 of the TNFalpha gene promoter region was found associated with CD as the TNF-308A allele appeared significantly increased in frequency in CD haplotypes, and this was shown to be independent of the association between CD and the DRB1*0301,DQA1*0501,DQB1*0201 alleles.
|
10773355 |
2000 |